abstract：:Male infertility represents one of the clearest examples of a complex disease with a substantial genetic basis. Numerous male mouse models, mutation screening and association studies reported over the last few years reveal the high prevalence of genetic causes of spermatogenic impairment, accounting for 10-15% of seve...

journal_title：Reproductive biomedicine online

authors： Ferlin A,Raicu F,Gatta V,Zuccarello D,Palka G,Foresta C

更新日期：2007-06-01 00:00:00

abstract：:The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) is founded to promote a more physiological, less drug-oriented, lower risk, less expensive and more patient friendly approach to Assisted Reproduction embracing not only natural cycle treatment but also gentle stimulation protocols and in-...

journal_title：Reproductive biomedicine online

authors： Nargund G,Frydman R

更新日期：2007-05-01 00:00:00

abstract：:Gonadotrophin-releasing hormone (GnRH) antagonists suppress gonadotrophin secretion resulting in dramatic reduction in treatment cycle duration. Assuming comparable clinical outcomes, these benefits may justify changing the standard long GnRH agonist protocol to GnRH antagonist regimens. To evaluate the evidence, data...

journal_title：Reproductive biomedicine online

authors： Al-Inany HG,Abou-Setta AM,Aboulghar M

更新日期：2007-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) have a negative impact on sperm DNA, leading to the formation of oxidative products such as 8-oxo-7,8-dihydroxyguanosine. This compound causes fragmentation and, thus, has a mutagenic effect. Patient treatment with oral antioxidant vitamins is, therefore, standard practice for male infert...

journal_title：Reproductive biomedicine online

authors： Ménézo YJ,Hazout A,Panteix G,Robert F,Rollet J,Cohen-Bacrie P,Chapuis F,Clément P,Benkhalifa M

更新日期：2007-04-01 00:00:00

abstract：:The aim of this study was to compare the clinical performance of Wallace and Labotect embryo transfer catheters in a single assisted reproduction centre. A total of 260 women undergoing embryo transfer were randomized between Wallace and Labotect catheters. When both catheters failed to negotiate the cervical canal, t...

journal_title：Reproductive biomedicine online

authors： Ata B,Isiklar A,Balaban B,Urman B

更新日期：2007-04-01 00:00:00

abstract：:In medicine the changes in therapies are the evidence of the progress in knowledge. But many examples concerning the treatment of early spontaneous abortion, late abortion, menopause, contraception and infertility show that gynaecologists and obstetricians change their treatments just as fashion designers change their...

journal_title：Reproductive biomedicine online

authors： Cohen J

更新日期：2007-04-01 00:00:00

abstract：:The aim of this study was, firstly, to define the different patterns of early cleavage (EC) observed at 26 h after either IVF or intracytoplasmic sperm injection (ICSI) and, secondly, to assess the predictive value of one of these patterns, even EC (EEC), on pregnancy rate in combination with day 2 embryo score. In th...

journal_title：Reproductive biomedicine online

authors： Terriou P,Giorgetti C,Hans E,Salzmann J,Charles O,Cignetti L,Avon C,Roulier R

更新日期：2007-03-01 00:00:00

abstract：:Older women comprise an increasing portion of patients entering assisted reproduction programmes. This study is a retrospective summary of the files of all patients aged 40 years and older at advent of IVF, between 1995 and 2004, in the authors' centre. In all, 381 women underwent 1217 initiated treatment cycles. Embr...

journal_title：Reproductive biomedicine online

authors： Tsafrir A,Simon A,Revel A,Reubinoff B,Lewin A,Laufer N

更新日期：2007-03-01 00:00:00

abstract：:Laparoscopic surgery with the assistance of the da Vinci robotic system has been recently introduced in gynaecology, as this new technology provides three-dimensional vision and easier suture capability. This study reports, for the first time, the case of an uncomplicated full term pregnancy after laparoscopic myomect...

journal_title：Reproductive biomedicine online

authors： Bocca S,Stadtmauer L,Oehninger S

更新日期：2007-02-01 00:00:00

abstract：:Multiple pregnancies are a serious adverse event of IVF treatment. Several strategies have been developed to improve embryo selection and embryo developmental potential to increase pregnancy rates without increasing the risk of multiple pregnancies. The only way to effectively solve this problem is to reduce the numbe...

journal_title：Reproductive biomedicine online

authors： Quea G,Romero K,Garcia-Velasco JA

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to identify predictors of fertilization rate (FR) and embryo quality (EQ) in 126 donor women who underwent 160 intracytoplasmic sperm injection (ICSI) cycles. Main outcome measures were oocyte dysmorphisms (OD) [perivitelline space (normal/large), perivitelline debris (no/yes), oocyte shape (...

journal_title：Reproductive biomedicine online

authors： Ten J,Mendiola J,Vioque J,de Juan J,Bernabeu R

更新日期：2007-01-01 00:00:00

abstract：:The Bertarelli Foundation aims to promote understanding of infertility. Two international conferences in 1999 and 2002 have highlighted the importance of multiple gestations, which have been recognized as a major problem associated with assisted reproductive technologies and ovulation induction therapies. For this rea...

journal_title：Reproductive biomedicine online

authors： Germond M

更新日期：2007-01-01 00:00:00

abstract：:The high incidence of multiple pregnancies after application of techniques for assisted reproduction is a phenomenon of major concern worldwide. High order multiples in particular have to be regarded as a serious adverse event. However, data show that in Europe, although the situation varies from country to country, m...

journal_title：Reproductive biomedicine online

authors： Felberbaum RE

更新日期：2007-01-01 00:00:00

abstract：:Comparative profiling was performed on proteins synthesized in human cumulus cells (CC) from individual oocytes recovered after two different ovarian stimulation protocols for classical IVF (cIVF). Using high-resolution two-dimensional protein electrophoresis after metabolic labelling with [35S]-methionine, protein ex...

journal_title：Reproductive biomedicine online

authors： Hamamah S,Matha V,Berthenet C,Anahory T,Loup V,Dechaud H,Hedon B,Fernandez A,Lamb N

更新日期：2006-12-01 00:00:00

abstract：:Since the development of assisted reproduction techniques most countries have witnessed increased rates of multiple pregnancy. Despite the guidelines proposed by various scientific societies these rates continue to be abnormally high. In Spain, as in other Mediterranean countries, a greater number of embryos are trans...

journal_title：Reproductive biomedicine online

authors： Tur R,Coroleu B,Torelló MJ,Boada M,Veiga A,Barri PN

更新日期：2006-12-01 00:00:00

abstract：:The aim of this meta-analysis was to compare the efficacy of gonadotrophin antagonist (GnRH-ant) versus GnRH agonist (GnRHa) as coadjuvant therapy for ovarian stimulation in poor ovarian responders in IVF/intracytoplasmic sperm injection cycles. Search strategies included on-line surveys of databases such as MEDLINE ,...

journal_title：Reproductive biomedicine online

authors： Franco JG Jr,Baruffi RL,Mauri AL,Petersen CG,Felipe V,Cornicelli J,Cavagna M,Oliveira JB

更新日期：2006-11-01 00:00:00

abstract：:Pre-eclampsia is a major disorder of human pregnancy, which may have an immunological basis. It is a disease of two stages. The first stage concerns the relative failure of early trophoblast invasion and remodelling of the spiral arteries, leading to a poor blood supply to the placenta, exposing it to oxidative stress...

journal_title：Reproductive biomedicine online

authors： Sargent IL,Borzychowski AM,Redman CW

更新日期：2006-11-01 00:00:00

abstract：:Early pregnancy loss (EPL) significantly reduces the initial success rate of assisted reproduction treatments and increases the psychological burden on the patient. The aim of the current study was to investigate the association between embryo quality and EPL in IVF. A retrospective study of 1471 women undergoing IVF ...

journal_title：Reproductive biomedicine online

authors： Hourvitz A,Lerner-Geva L,Elizur SE,Baum M,Levron J,David B,Meirow D,Yaron R,Dor J

更新日期：2006-10-01 00:00:00

abstract：:This paper examines the importance of a clinical diagnosis in the management of infertility in the male and discusses the reasons for this statement. The treatment of male infertility is now often carried out solely by gynaecologists. These specialists have frequently had little training in the examination of the male...

journal_title：Reproductive biomedicine online

authors： Jequier AM

更新日期：2006-09-01 00:00:00

abstract：:Understanding the biology of reproductive organs is essential for the development of assisted reproductive techniques. There is at present no direct evidence for either the concentration and dynamics of intrauterine oxygen tension at the endometrial surface, nor its importance for the receptiveness of the endometrium....

journal_title：Reproductive biomedicine online

authors： Ottosen LD,Hindkaer J,Husth M,Petersen DE,Kirk J,Ingerslev HJ

更新日期：2006-09-01 00:00:00

abstract：:The revolutionary development of biotechnology-derived therapeutic proteins has provided the expected improvements in quality, purity and consistency, as demonstrated in recombinant human FSH (rhFSH). However, the development of urine-derived gonadotrophins has not always shown comparable improvements. More recently, ...

journal_title：Reproductive biomedicine online

authors： Lispi M,Bassett R,Crisci C,Mancinelli M,Martelli F,Ceccarelli D,De Bellis C,Mendola D

更新日期：2006-08-01 00:00:00

abstract：:The spatial specificity and stability of subplasmalemmal domains of high-polarized mitochondria (Delta Psi m(HIGH)) in human oocytes and cleavage stage embryos were investigated in instances where changes in pericortical/subplasmalemmal organization resulted in the corresponding cytoplasm becoming translucent and larg...

journal_title：Reproductive biomedicine online

authors： Van Blerkom J,Davis P

更新日期：2006-08-01 00:00:00

abstract：:Egg sharing remains a controversial practice, mainly because of the presumed element of payment. In order to find out to what extent financial considerations motivated the women to share their oocytes, the data on egg sharing in Belgium are analysed. Belgium began providing full reimbursement for six in-vitro fertiliz...

journal_title：Reproductive biomedicine online

authors： Pennings G,Devroey P

更新日期：2006-07-01 00:00:00

abstract：:Endometriosis is more frequently diagnosed in patients with infertility than in a normal population. The goal of this paper is to give an overview of the clinical and fundamental evidence for a possible link between endometriosis and (recurrent) miscarriage or implantation failure after treatment with assisted reprodu...

journal_title：Reproductive biomedicine online

authors： Tomassetti C,Meuleman C,Pexsters A,Mihalyi A,Kyama C,Simsa P,D'Hooghe TM

更新日期：2006-07-01 00:00:00

abstract：:Preimplantation genetic aneuploidy screening performed by polar body biopsy has become a frequently used method, especially as in several countries only preconceptional genetic diagnosis is allowed. To penetrate the zona pellucida, mechanical, chemical and laser-assisted techniques have been introduced. In this paper,...

journal_title：Reproductive biomedicine online

authors： Dawson A,Griesinger G,Diedrich K

更新日期：2006-07-01 00:00:00

abstract：:In their quest for a child, infertile couples embark on a journey that is full of expectations and hopes. Over recent years, treatment procedures for assisted conception have become safer and more efficient. However, couples undergoing treatment can still experience some degree of emotional stress due to disappointmen...

journal_title：Reproductive biomedicine online

authors： Wikland M,Hugues JN,Howles C

更新日期：2006-06-01 00:00:00

abstract：:Polycystic ovarian syndrome (PCOS) is a common endocrine condition with reproductive and metabolic consequences, including anovulation, infertility and an increased prevalence of diabetes mellitus. Obesity, central obesity and insulin resistance are strongly implicated in its aetiology. Dietary weight loss is recommen...

journal_title：Reproductive biomedicine online

authors： Moran LJ,Brinkworth G,Noakes M,Norman RJ

更新日期：2006-05-01 00:00:00

abstract：:The role of LH in ovarian stimulation continues to be controversial. Most observational studies on both gonadotrophin-releasing hormone (GnRH) agonist and GnRH antagonist protocols failed to show an effect on ongoing pregnancy likelihood of punctually measured 'low' or 'high' endogenous LH concentrations during ovaria...

journal_title：Reproductive biomedicine online

authors： Griesinger G,Diedrich K

更新日期：2006-04-01 00:00:00

abstract：:Meta-analyses were conducted to investigate the relationship of sperm DNA fragmentation on pregnancy outcome using in-vivo fertilization, IUI, routine IVF and ICSI. Couples with no known infertility problems were 7.0 times (CI 3.17, 17.7) more likely to achieve a pregnancy/delivery if the DNA fragmentation index (DFI)...

journal_title：Reproductive biomedicine online

authors： Evenson D,Wixon R

更新日期：2006-04-01 00:00:00

abstract：:The fear that the ethics and practice of egg sharing will be undermined by the growing success of oocyte cryopreservation is not based on published evidence. Separate contracts and directed counselling of donors and recipients as required by law in the UK provide protection against potential pitfalls with egg sharing....

journal_title：Reproductive biomedicine online

authors： Ahuja KK,Simons EG

更新日期：2006-03-01 00:00:00

abstract：:While the role of inherited thrombophilia has been accepted as a cause of recurrent late pregnancy complications, the contribution of mutated thrombophilic genes to implantation failure has not been studied. Proteins involved in fibrinolysis are necessary for trophoblast invasion into the endometrium. This study compa...

journal_title：Reproductive biomedicine online

authors： Coulam CB,Jeyendran RS,Fishel LA,Roussev R

更新日期：2006-03-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) has been associated with low expression of apoptosis-and angiogenesis-related genes. The p53 tumour suppressor gene has been shown to induce apoptosis and angiogenesis. Recently, a low increased frequency of a p53 codon 72 polymorphism has been reported among women experiencing RPL. This...

journal_title：Reproductive biomedicine online

authors： Coulam CB,Kay C,Jeyendran RS

更新日期：2006-03-01 00:00:00

abstract：:A method has been developed of injecting gonadotrophins vaginally every 3-4 days, to reduce both the dose and frequency of injections. A couple with primary infertility for 5 years with a previous failed IVF cycle was recruited. A total dose of 1200 IU gonadotrophins was administered in three injections. Ten mature oo...

journal_title：Reproductive biomedicine online

authors： Hsu CC,Hsu CT

更新日期：2006-02-01 00:00:00

abstract：:Preimplantation genetic diagnosis (PGD) may help couples at risk to avoid pregnancies with known genetic diseases. In Germany, the only option to perform PGD is the analysis of polar bodies (PB). Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder. Q70X is one of the frequent dise...

journal_title：Reproductive biomedicine online

authors： Tomi D,Schultze-Mosgau A,Eckhold J,Schopper B,Al-Hasani S,Steglich C,Gal A,Axt-Fliedner R,Schwinger E,Diedrich K,Griesinger G

更新日期：2006-02-01 00:00:00

abstract：:Due to inherent differences between gonadotrophin-releasing hormone (GnRH) antagonists and agonists, their late effect on ovarian steroidal production during the luteal phase of IVF cycles may differ. The aim of this study was to characterize and compare the luteal phase hormonal profile after the use of GnRH antagoni...

journal_title：Reproductive biomedicine online

authors： Friedler S,Gilboa S,Schachter M,Raziel A,Strassburger D,Ron El R

更新日期：2006-01-01 00:00:00

abstract：:Many high-grade embryos selected for transfer according to their morphological evaluation were detected to have chromosomal abnormalities after aneuploidy screening for infertility by preimplantation genetic diagnosis (PGD). The aim of this study was to detect if there is any correlation between embryo quality and gen...

journal_title：Reproductive biomedicine online

authors： Baltaci V,Satiroglu H,Kabukçu C,Unsal E,Aydinuraz B,Uner O,Aktas Y,Cetinkaya E,Turhan F,Aktan A

更新日期：2006-01-01 00:00:00

abstract：:To investigate the possible beneficial effect of a new stimulation protocol (termed 'CRASH') on the outcome of poor responder patients, a multicentre, prospective longitudinal study including a total of 36 women undergoing 72 IVF/intracytoplasmic sperm injection (ICSI) cycles with patients serving as their own control...

journal_title：Reproductive biomedicine online

authors： Humaidan P,Bungum L,Bungum M,Hald F,Agerholm I,Blaabjerg J,Yding Andersen C,Lindenberg S

更新日期：2005-12-01 00:00:00

abstract：:This study sought to assess the efficacy of intravenous immunoglobulin (IVIg) in improving pregnancy rates and outcome, in a select group of patients with repeated IVF failure and human leukocyte antigen (HLA) similarity. Couples suffering from recurrent IVF failure, defined as at least seven attempts at embryo transf...

journal_title：Reproductive biomedicine online

authors： Elram T,Simon A,Israel S,Revel A,Shveiky D,Laufer N

更新日期：2005-12-01 00:00:00

abstract：:This study aimed to establish whether patients who receive support counselling by the embryologist as counsellor during assisted reproduction procedures would be better equipped with efficient coping mechanisms than patients who were not counselled. Sixty patients were randomly assigned to either the support counselli...

journal_title：Reproductive biomedicine online

authors： van Zyl C,van Dyk AC,Niemandt C

更新日期：2005-11-01 00:00:00

abstract：:Glucose uptake was used as a measure of metabolic activity and implantation potential to compare vitrification and slow freezing in a prospective randomized trial using murine blastocysts. Frozen 2-cell embryos (n = 132) thawed and cultured for 48 h to the blastocyst stage were randomly divided into four groups: (i) c...

journal_title：Reproductive biomedicine online

authors： Walker DL,Gardner DK,Lane M,Tummon IS,Session DR,Thornhill AR

更新日期：2005-11-01 00:00:00